THC is a cannabinoid, but what’s a cannabinoid?The first step to understanding THC is to understand cannabinoids. Cannabinoids are chemical compounds found in the cannabis plant that interact with receptors in the brain and body to create various effects. There exist dozens, and potentially more than 100, cannabinoids in the cannabis plant, but THC is most widely known among these due to its abundance and euphoric attributes. The isolation of THC came from an Israeli chemist by the name of Raphael Mechoulam. In 1964, Mechoulam isolated and synthesized THC from Lebanese hashish, marking the beginning of cannabis research that would lead to the discovery of many other cannabinoids, cannabinoid receptors throughout the body, and “endocannabinoids” – the THC-like compounds our body naturally produces to maintain stability and health. Why does cannabis produce cannabinoids? Cannabinoids are known as secondary metabolites, which means they are chemicals the plant produces that have no primary role on the plant’s development. However, the leading hypothesisis that secondary metabolites act as an immune system for the plant, fending off predators, parasites, and pests. Because humans (and many other animals) have receptor systems that THC binds to, we can also reap the benefits of cannabinoids for both health and enjoyment. This system, called the endocannabinoid system (or ECS), is a group of specialized signaling chemicals (think “keys”), their receptors (think “locks”), and the metabolic enzymes that produce and break them down. These endocannabinoid chemical signals act on some of the same brain and immune cell receptors (CB1 and CB2) that plant cannabinoids like cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) act on.
How does THC produce its effects and get us high?
What to expect from a THC highTHC has a wide range of short-term effects which may or may not be experienced depending on the individual. For example, while some may find that THC elicits strong feelings of calm and peace, others may notice an increase in their anxiety levels. The difference can be as simple as one’s own body chemistry, but certain strains and varying concentrations of THC can also create different outcomes in how one feels. If one cannabis strain elicits unpleasant feelings, another may be just the right medley to induce a very enjoyable sensation. Consider consulting a thorough strain database to find what’s right for you, and as always, it’s wise to “start low and go slow” – consume a little at a time and then wait to see how you feel. Remember, a cannabis high can last for a few hours, but it will wear off. Some short-term effects of THC include:
- Pain relief
- Memory impairment
- Increased heart rate
- Dry mouth
- Red eyes
- Slowed perception of time
- “Couch-lock,” or feeling heavy
What are the risks and long-term effects of THC?
What are the medicinal effects of THC?
- Neuropathic and chronic pain
- Crohn’s disease
- Alzheimer’s disease
- Multiple sclerosis
- Sleep apnea
- Appetite loss